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4civ

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4civ| PDB=4civ | SCENE= }}
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===Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid===
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{{ABSTRACT_PUBMED_24689821}}
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The entry 4civ is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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Authors: Otero, J.M., Llamas-Saiz, A.L., Lamb, H., Hawkins, A.R., Blanco, B., Sedes, A., Peon, A., Gonzalez-Bello, C., vanRaaij, M.J.
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==About this Structure==
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[[4civ]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIV OCA].
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Description: Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid
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==Reference==
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<ref group="xtra">PMID:024689821</ref><references group="xtra"/><references/>
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[[Category: 3-dehydroquinate dehydratase]]
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[[Category: Blanco, B.]]
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[[Category: Gonzalez-Bello, C.]]
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[[Category: Hawkins, A R.]]
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[[Category: Lamb, H.]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Otero, J M.]]
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[[Category: Peon, A.]]
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[[Category: Sedes, A.]]
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[[Category: VanRaaij, M J.]]
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[[Category: Bacterial protein]]
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[[Category: Inhibitor]]
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[[Category: Lyase]]
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[[Category: Protein binding]]
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[[Category: Shikimis acid pathway]]
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[[Category: Substrate specificity]]

Revision as of 09:42, 16 April 2014

Template:STRUCTURE 4civ

Contents

Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid

Template:ABSTRACT PUBMED 24689821

Function

[AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]

About this Structure

4civ is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors. J Med Chem. 2014 Apr 1. PMID:24689821 doi:http://dx.doi.org/10.1021/jm500175z

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OCA

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