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4nwl

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'''Unreleased structure'''
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{{STRUCTURE_4nwl| PDB=4nwl | SCENE= }}
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===Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide===
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{{ABSTRACT_PUBMED_24555570}}
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The entry 4nwl is ON HOLD
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==About this Structure==
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[[4nwl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWL OCA].
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Authors: Muckelbauer, J.K., Klei, H.E.
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==Reference==
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<ref group="xtra">PMID:024555570</ref><references group="xtra"/><references/>
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Description: Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide
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[[Category: Klei, H E.]]
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[[Category: Muckelbauer, J K.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydrolase/hydrolase inhibitor]]
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[[Category: Serine protease]]

Revision as of 09:17, 26 March 2014

Template:STRUCTURE 4nwl

Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide

Template:ABSTRACT PUBMED 24555570

About this Structure

4nwl is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Scola PM, Wang AX, Good AC, Sun LQ, Combrink KD, Campbell JA, Chen J, Tu Y, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea S, Zheng B, Hewawasam P, Ding M, Thuring J, Li J, Hernandez D, Yu F, Falk P, Zhai G, Sheaffer AK, Chen C, Lee MS, Barry D, Knipe JO, Li W, Han YH, Jenkins S, Gesenberg C, Gao Q, Sinz MW, Santone KS, Zvyaga T, Rajamani R, Klei HE, Colonno RJ, Grasela DM, Hughes E, Chien C, Adams S, Levesque PC, Li D, Zhu J, Meanwell NA, McPhee F. Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J Med Chem. 2014 Mar 13;57(5):1708-29. doi: 10.1021/jm401840s. Epub 2014 Feb 20. PMID:24555570 doi:http://dx.doi.org/10.1021/jm401840s

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OCA

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