4o9r

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'''Unreleased structure'''
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==Human Smoothened Receptor structure in complex with cyclopamine==
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<StructureSection load='4o9r' size='340' side='right' caption='[[4o9r]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9R FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY8:CYCLOPAMINE'>CY8</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9r RCSB], [http://www.ebi.ac.uk/pdbsum/4o9r PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography. Data collected from sub-10-mum-sized crystals produced with less than 0.5 mg of purified protein yield structural insights regarding cyclopamine binding to the Smoothened receptor.
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The entry 4o9r is ON HOLD
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Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.,Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V Nat Commun. 2014;5:3309. doi: 10.1038/ncomms4309. PMID:24525480<ref>PMID:24525480</ref>
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Authors: Wang, C., Weierstall, U., James, D., White, T.A., Wang, D., Liu, W., Spence, J.C.H., Doak, R.B., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N.A., Liu, H., Basu, S., Wacker, D., Han, G.W., Katritch, V., Boutet, S., Messerschmidt, M., Willams, G.J., Koglin, J.E., Seibert, M.M., Klinker, M., Gati, C., Shoeman, R.L., Barty, A., Chapman, H.N., Kirian, R.A., Beyerlein, K.R., Stevens, R.C., Li, D., Shah, S.T.A., Howe, N., Caffrey, M., Cherezov, V., GPCR Network (GPCR)
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Human Smoothened Receptor structure in complex with cyclopamine
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Barty, A.]]
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[[Category: Basu, S.]]
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[[Category: Beyerlein, K R.]]
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[[Category: Boutet, S.]]
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[[Category: Caffrey, M.]]
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[[Category: Chapman, H N.]]
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[[Category: Cherezov, V.]]
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[[Category: Doak, R B.]]
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[[Category: Fromme, P.]]
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[[Category: Fromme, R.]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: Gati, C.]]
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[[Category: Grotjohann, I.]]
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[[Category: Han, G W.]]
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[[Category: Howe, N.]]
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[[Category: James, D.]]
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[[Category: Katritch, V.]]
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[[Category: Kirian, R A.]]
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[[Category: Klinker, M.]]
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[[Category: Koglin, J E.]]
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[[Category: Kupitz, C.]]
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[[Category: Li, D.]]
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[[Category: Liu, H.]]
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[[Category: Liu, W.]]
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[[Category: Messerschmidt, M.]]
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[[Category: Nelson, G.]]
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[[Category: Seibert, M M.]]
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[[Category: Shah, S T.A.]]
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[[Category: Shoeman, R L.]]
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[[Category: Spence, J C.H.]]
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[[Category: Stevens, R C.]]
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[[Category: Wacker, D.]]
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[[Category: Wang, C.]]
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[[Category: Wang, D.]]
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[[Category: Weierstall, U.]]
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[[Category: White, T A.]]
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[[Category: Willams, G J.]]
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[[Category: Zatsepin, N A.]]
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[[Category: Cyclopamine]]
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[[Category: Free electron laser]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Human smo receptor]]
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[[Category: Lcp]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Room temperature structure]]
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[[Category: Serial femtosecond crystallography]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Xfel]]

Revision as of 12:34, 18 May 2014

Human Smoothened Receptor structure in complex with cyclopamine

4o9r, resolution 3.20Å

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