4o2w
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the third RCC1-like domain of HERC1== | |
| - | + | <StructureSection load='4o2w' size='340' side='right' caption='[[4o2w]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4o2w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O2W FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HERC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o2w RCSB], [http://www.ebi.ac.uk/pdbsum/4o2w PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | [[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: Arrowsmith, C H | + | </StructureSection> |
| - | [[Category: Bountra, C | + | [[Category: Human]] |
| - | [[Category: Dong, A | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Edwards, A M | + | [[Category: Bountra, C]] |
| - | [[Category: Hu, J | + | [[Category: Dong, A]] |
| - | [[Category: Li, Y | + | [[Category: Edwards, A M]] |
| - | [[Category: | + | [[Category: Hu, J]] |
| - | [[Category: Tong, Y | + | [[Category: Li, Y]] |
| - | [[Category: Walker, J R | + | [[Category: Structural genomic]] |
| + | [[Category: Tong, Y]] | ||
| + | [[Category: Walker, J R]] | ||
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Herc1]] | [[Category: Herc1]] | ||
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[[Category: Rld]] | [[Category: Rld]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 02:52, 25 December 2014
Crystal structure of the third RCC1-like domain of HERC1
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Categories: Human | Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Hu, J | Li, Y | Structural genomic | Tong, Y | Walker, J R | Beta-propeller | Herc1 | Ligase | Rcc1 | Rld | Sgc
