2mju

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m (Protected "2mju" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2mju| PDB=2mju | SCENE= }}
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===Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)===
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The entry 2mju is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PTBP2_HUMAN PTBP2_HUMAN]] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.<ref>PMID:11003644</ref> <ref>PMID:12667457</ref>
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Authors: Esteve, V., Blatter, M., Allain, F.H.-T.
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==About this Structure==
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[[2mju]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJU OCA].
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Description: Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Allain, F H.T.]]
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[[Category: Blatter, M.]]
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[[Category: Esteve, V.]]
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[[Category: Nptb]]
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[[Category: Splicing]]

Revision as of 05:12, 13 February 2014

Template:STRUCTURE 2mju

Contents

Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

Function

[PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.[1] [2]

About this Structure

2mju is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(20):7463-79. PMID:11003644
  2. ↑ Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003 Mar;11(3):757-71. PMID:12667457

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