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4cl9
From Proteopedia
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| - | ''' | + | ==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH I-BET295== |
| - | + | <StructureSection load='4cl9' size='340' side='right' caption='[[4cl9]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4cl9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CL9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IES:PROPAN-2-YL+N-[(2S,4R)-1-ETHANOYL-2-METHYL-6-[4-[[8-(OXIDANYLAMINO)-8-OXIDANYLIDENE-OCTANOYL]AMINO]PHENYL]-3,4-DIHYDRO-2H-QUINOLIN-4-YL]CARBAMATE'>IES</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4clb|4clb]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cl9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cl9 PDBsum]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Atkinson, S]] | ||
| + | [[Category: Chung, C]] | ||
| + | [[Category: Antagonist]] | ||
| + | [[Category: Epigenetic reader]] | ||
| + | [[Category: Histone]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 11:04, 24 December 2014
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH I-BET295
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