4o61

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'''Unreleased structure'''
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{{STRUCTURE_4o61| PDB=4o61 | SCENE= }}
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===Structure of human ALKBH5 crystallized in the presence of citrate===
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The entry 4o61 is ON HOLD until Feb 22 2015
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==Function==
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[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
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Authors: Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4o61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O61 OCA].
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Description: Structure of human ALKBH5 crystallized in the presence of citrate
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Cerovina, T.]]
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[[Category: Chao, X.]]
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[[Category: Dong, A.]]
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[[Category: Edwards, A M.]]
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[[Category: He, H.]]
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[[Category: Liu, K.]]
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[[Category: Min, J.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel, W.]]
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[[Category: Dioxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Rna demethylase]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]

Revision as of 18:27, 3 March 2014

Template:STRUCTURE 4o61

Contents

Structure of human ALKBH5 crystallized in the presence of citrate

Function

[ALKB5_HUMAN] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.[1] [2]

About this Structure

4o61 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schodel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). PLoS One. 2011 Jan 14;6(1):e16210. doi: 10.1371/journal.pone.0016210. PMID:21264265 doi:http://dx.doi.org/10.1371/journal.pone.0016210
  2. ↑ Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012, Nov 21. PMID:23177736 doi:http://dx.doi.org/10.1016/j.molcel.2012.10.015

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