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4o76

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'''Unreleased structure'''
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{{STRUCTURE_4o76| PDB=4o76 | SCENE= }}
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===Crystal structure of the first bromodomain of human BRD4 in complex with TG101209===
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{{ABSTRACT_PUBMED_24568369}}
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The entry 4o76 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Zhu, J.-Y., Ember, S.W., Watts, C., Schonbrunn, E.
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description:
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==About this Structure==
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[[4o76]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O76 OCA].
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==Reference==
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<ref group="xtra">PMID:024568369</ref><references group="xtra"/><references/>
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[[Category: Ember, S W.]]
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[[Category: Schonbrunn, E.]]
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[[Category: Watts, C.]]
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[[Category: Zhu, J Y.]]
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[[Category: Bromodomain]]
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[[Category: Cap]]
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[[Category: Cell cycle]]
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[[Category: Hunk1]]
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[[Category: Inhibitor]]
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[[Category: Mcap]]
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[[Category: Mitotic chromosome associated protein]]
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[[Category: Protein binding-inhibitor complex]]
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[[Category: Transcription-inhibitor complex]]

Revision as of 08:44, 19 March 2014

Template:STRUCTURE 4o76

Contents

Crystal structure of the first bromodomain of human BRD4 in complex with TG101209

Template:ABSTRACT PUBMED 24568369

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4o76 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E. Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. ACS Chem Biol. 2014 Mar 13. PMID:24568369 doi:http://dx.doi.org/10.1021/cb500072z
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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