2zb0

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[[Image:2zb0.jpg|left|200px]]<br /><applet load="2zb0" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2zb0.jpg|left|200px]]
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caption="2zb0, resolution 2.100&Aring;" />
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'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''<br />
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{{Structure
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|PDB= 2zb0 |SIZE=350|CAPTION= <scene name='initialview01'>2zb0</scene>, resolution 2.100&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=GK3:'>GK3</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24]
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|GENE=
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}}
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'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ZB0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GK3:'>GK3</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZB0 OCA].
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2ZB0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZB0 OCA].
==Reference==
==Reference==
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Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18006306 18006306]
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Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18006306 18006306]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Mitogen-activated protein kinase]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:27 2008''

Revision as of 16:53, 20 March 2008

Image:2zb0.jpg


PDB ID 2zb0

Drag the structure with the mouse to rotate
, resolution 2.100Å
Ligands: and
Activity: Mitogen-activated protein kinase, with EC number 2.7.11.24
Coordinates: save as pdb, mmCIF, xml



Crystal structure of P38 in complex with biphenyl amide inhibitor


Overview

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

About this Structure

2ZB0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306

Page seeded by OCA on Thu Mar 20 18:53:27 2008

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