4o8x

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{{STRUCTURE_4o8x| PDB=4o8x | SCENE= }}
{{STRUCTURE_4o8x| PDB=4o8x | SCENE= }}
===Zinc-bound Rpn11 in complex with Rpn8===
===Zinc-bound Rpn11 in complex with Rpn8===
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{{ABSTRACT_PUBMED_24463465}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024463465</ref><references group="xtra"/><references/>
[[Category: Martin, A.]]
[[Category: Martin, A.]]
[[Category: Padovani, C.]]
[[Category: Padovani, C.]]

Revision as of 14:23, 3 March 2014

Template:STRUCTURE 4o8x

Contents

Zinc-bound Rpn11 in complex with Rpn8

Template:ABSTRACT PUBMED 24463465

Function

[RPN8_YEAST] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.[1] [RPN11_YEAST] Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.[2]

About this Structure

4o8x is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Worden EJ, Padovani C, Martin A. Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation. Nat Struct Mol Biol. 2014 Jan 23. doi: 10.1038/nsmb.2771. PMID:24463465 doi:http://dx.doi.org/10.1038/nsmb.2771
  1. ↑ Glickman MH, Rubin DM, Fried VA, Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol. 1998 Jun;18(6):3149-62. PMID:9584156
  2. ↑ Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K. Sts1 plays a key role in targeting proteasomes to the nucleus. J Biol Chem. 2011 Jan 28;286(4):3104-18. doi: 10.1074/jbc.M110.135863. Epub 2010 , Nov 12. PMID:21075847 doi:10.1074/jbc.M110.135863

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OCA

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