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Acyl-CoA dehydrogenase
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | + | ===Short chain ACDH=== | |
[[1jqi]] - SCAD + acetoacetyl-CoA + FAD – rat<BR /> | [[1jqi]] - SCAD + acetoacetyl-CoA + FAD – rat<BR /> | ||
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[[2jif]], [[2vig]] - hSCAD + CoA persulfide + FAD – human | [[2jif]], [[2vig]] - hSCAD + CoA persulfide + FAD – human | ||
| - | + | ===Medium chain ACDH=== | |
[[1ws9]], [[2cx9]] - TtMCAD <BR /> | [[1ws9]], [[2cx9]] - TtMCAD <BR /> | ||
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[[2a1t]] - hMCAD + electron transfer flavoprotein (mutant) + AMP + FAD<BR /> | [[2a1t]] - hMCAD + electron transfer flavoprotein (mutant) + AMP + FAD<BR /> | ||
| - | + | ===Very long chain ACDH=== | |
[[2uxw]] - hVLCAD + tetradecanoyl CoA + FAD<BR /> | [[2uxw]] - hVLCAD + tetradecanoyl CoA + FAD<BR /> | ||
[[3b96]] - hVLCAD + trans-δ2-palmitenoyl CoA + FAD<BR /> | [[3b96]] - hVLCAD + trans-δ2-palmitenoyl CoA + FAD<BR /> | ||
| - | + | ===Unspecified length ACDH=== | |
[[2oku]] – ACDH C terminal – ''Porphyromonas gingivalis''<BR /> | [[2oku]] – ACDH C terminal – ''Porphyromonas gingivalis''<BR /> | ||
Revision as of 08:15, 14 August 2014
Acyl-CoA dehydrogenase (ACDH) catalyzes the introduction of a double bond between C2 and C3 of the thio-ester CoA substrate. This is the first reaction in fatty acid metabolism which produces acetyl-CoA. FAD is the cofactor of ACDH activity. ACDH is classified according to the length of its substrates as short- (SCAD), medium- (MCAD), very- and very long-chain (VLCAD) ACDH. Impairment of the activity of ACDH causes a variety of diseases associated with lack of fatty acid metabolism.
Contents |
3D structures of acyl-CoA dehydrogenase
Updated on 14-August-2014
Short chain ACDH
1jqi - SCAD + acetoacetyl-CoA + FAD – rat
2dvl, 2z1q - TtSCAD + FAD – Thermus thermophilus
2jif, 2vig - hSCAD + CoA persulfide + FAD – human
Medium chain ACDH
1ws9, 2cx9 - TtMCAD
3mdd – pMCAD + FAD – pig
1egd, 1ege - hMCAD (mutant) + FAD
1ukw, 2d29 - TtMCAD + FAD
1egc - hMCAD (mutant) + octanoyl-CoA + FAD
3mde - pMCAD + octanoyl-CoA + FAD
1udy - pMCAD + thiaoctanoyl-CoA + FAD
1t9g - hMCAD + electron transfer flavoprotein + AMP + FAD
2a1t - hMCAD + electron transfer flavoprotein (mutant) + AMP + FAD
Very long chain ACDH
2uxw - hVLCAD + tetradecanoyl CoA + FAD
3b96 - hVLCAD + trans-δ2-palmitenoyl CoA + FAD
Unspecified length ACDH
2oku – ACDH C terminal – Porphyromonas gingivalis
2pg0 - ACDH + FAD – Geobacillus kaustophilus
2wbi – hACDH 11 + FAD
3nf4, 3pfd – ACHD + FAD – Mycobacterium thermoresistibile
3oib - ACHD + FAD – Mycobacterium smegmatis
4m9a – ACDH + FAD – Burkholderia thailandensis
3owa - ACDH + FAD – Bacillus anthracis
