ADP-ribose pyrophosphatase
From Proteopedia
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[[2w4e]] – ADPRP residues 56-200 – ''Deinococcus radiodurans''<br /> | [[2w4e]] – ADPRP residues 56-200 – ''Deinococcus radiodurans''<br /> | ||
[[3o8s]] - ADPRP – ''Streptococcus suis''<br /> | [[3o8s]] - ADPRP – ''Streptococcus suis''<br /> | ||
| - | [[4kyx]] – ADPRP | + | [[4kyx]] – ADPRP Mutt – ''Rickettsia felis''<br /> |
'''ADP-ribose pyrophosphatase binary complex''' | '''ADP-ribose pyrophosphatase binary complex''' | ||
Revision as of 11:27, 26 January 2014
ADP-ribose pyrophosphatase (ADPRP) catalyzes the reaction which converts ADP-ribose to AMP and D-ribose 5-phosphate. ADPRP contains Mg+2 ion. The C terminal of ADPRP contains the Nudix sequence which binds the metal ion. ADPRP regulates the level of ADP-ribose (ADPR) in the cell. Excess of ADPR can inactivate proteins with nucleotide-binding site by binding to them.
3D structures of ADP-ribose pyrophosphatase
Updated on 26-January-2014
1q33 – hADPRP NUDT9 residues 59-350 – human
1v8i - TtADPRP – Thermus thermophilus
2w4e – ADPRP residues 56-200 – Deinococcus radiodurans
3o8s - ADPRP – Streptococcus suis
4kyx – ADPRP Mutt – Rickettsia felis
ADP-ribose pyrophosphatase binary complex
1v8l – TtADPRP + ADPR
1v8n - TtADPRP + Zn
ADP-ribose pyrophosphatase ternary complex
1khz - EcADPRP + AMPCPR + Mg – Escherichia coli
1qvj - hADPRP + ribose-5-phosphate + Mg
1v8m - TtADPRP + Gd + ADPR
1v8s - TtADPRP + AMP + Mg
1v8t - TtADPRP + ribose-5-phosphate + Zn
1v8u - TtADPRP (mutant) + sulfate + Mg
1v8v - TtADPRP (mutant) + ADPR + Mg
1v8w - TtADPRP (mutant) + sulfate + Zn
1v8y - TtADPRP (mutant) + ADPR + Zn
1v8r - TtADPRP + ADPR + Zn
3bm4 - hADPRP NUDT5 + AMPCPR + Mg
