365d

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[[Image:365d.gif|left|200px]]<br /><applet load="365d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:365d.gif|left|200px]]
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caption="365d, resolution 2.000&Aring;" />
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'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''<br />
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{{Structure
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|PDB= 365d |SIZE=350|CAPTION= <scene name='initialview01'>365d</scene>, resolution 2.000&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=IIP:IMIDAZOLE-PYRROLE POLYAMIDE'>IIP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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365D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=IIP:'>IIP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA].
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365D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA].
==Reference==
==Reference==
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Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461074 9461074]
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Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461074 9461074]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Baird, E E.]]
[[Category: Baird, E E.]]
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[[Category: modified]]
[[Category: modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:59 2008''

Revision as of 16:55, 20 March 2008

Image:365d.gif


PDB ID 365d

Drag the structure with the mouse to rotate
, resolution 2.000Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE


Overview

Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.

About this Structure

365D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074

Page seeded by OCA on Thu Mar 20 18:54:59 2008

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