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359d

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[[Image:359d.jpg|left|200px]]<br /><applet load="359d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:359d.jpg|left|200px]]
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caption="359d, resolution 2.900&Aring;" />
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'''INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)'''<br />
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{{Structure
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|PDB= 359d |SIZE=350|CAPTION= <scene name='initialview01'>359d</scene>, resolution 2.900&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=TB:TERBIUM(III) ION'>TB</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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359D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=TB:'>TB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=359D OCA].
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359D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=359D OCA].
==Reference==
==Reference==
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Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb., Feig AL, Scott WG, Uhlenbeck OC, Science. 1998 Jan 2;279(5347):81-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9417029 9417029]
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Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb., Feig AL, Scott WG, Uhlenbeck OC, Science. 1998 Jan 2;279(5347):81-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9417029 9417029]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Feig, A L.]]
[[Category: Feig, A L.]]
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[[Category: rna hammerhead ribozyme]]
[[Category: rna hammerhead ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:57 2008''

Revision as of 16:54, 20 March 2008

Image:359d.jpg


PDB ID 359d

Drag the structure with the mouse to rotate
, resolution 2.900Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)


Overview

Terbium(III) [Tb(III)] was shown to inhibit the hammerhead ribozyme by competing with a single magnesium(II) ion. X-ray crystallography revealed that the Tb(III) ion binds to a site adjacent to an essential guanosine in the catalytic core of the ribozyme, approximately 10 angstroms from the cleavage site. Synthetic modifications near this binding site yielded an RNA substrate that was resistant to Tb(III) binding and capable of being cleaved, even in the presence of up to 20 micromolar Tb(III). It is suggested that the magnesium(II) ion thought to bind at this site may act as a switch, affecting the conformational changes required to achieve the transition state.

About this Structure

359D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb., Feig AL, Scott WG, Uhlenbeck OC, Science. 1998 Jan 2;279(5347):81-4. PMID:9417029

Page seeded by OCA on Thu Mar 20 18:54:57 2008

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