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399d
From Proteopedia
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| - | [[Image:399d.gif|left|200px]] | + | [[Image:399d.gif|left|200px]] |
| - | + | ||
| - | '''STRUCTURE OF D(CGCCCGCGGGCG)''' | + | {{Structure |
| + | |PDB= 399d |SIZE=350|CAPTION= <scene name='initialview01'>399d</scene>, resolution 1.9Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF D(CGCCCGCGGGCG)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 399D is a [ | + | 399D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http:// | + | Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Fernandez, L G.]] | [[Category: Fernandez, L G.]] | ||
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[[Category: double helix]] | [[Category: double helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:55:21 2008'' |
Revision as of 16:55, 20 March 2008
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| , resolution 1.9Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF D(CGCCCGCGGGCG)
Overview
We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.
About this Structure
399D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:9917405
Page seeded by OCA on Thu Mar 20 18:55:21 2008
