3b7o

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[[Image:3b7o.gif|left|200px]]<br /><applet load="3b7o" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3b7o.gif|left|200px]]
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caption="3b7o, resolution 1.60&Aring;" />
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'''Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site'''<br />
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{{Structure
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|PDB= 3b7o |SIZE=350|CAPTION= <scene name='initialview01'>3b7o</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MLT:MALATE ION'>MLT</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
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|GENE= PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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3B7O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MLT:'>MLT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7O OCA].
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3B7O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7O OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: sh2 domain]]
[[Category: sh2 domain]]
[[Category: shp2]]
[[Category: shp2]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: structural genomics consortium]]
[[Category: tyrosine phosphatase]]
[[Category: tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:03:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:56:49 2008''

Revision as of 16:56, 20 March 2008

Image:3b7o.gif


PDB ID 3b7o

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands:
Gene: PTPN11, PTP2C, SHPTP2 (Homo sapiens)
Activity: Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site


Disease

Known diseases associated with this structure: Leopard syndrome OMIM:[176876], Leukemia, juvenile myelomonocytic OMIM:[176876], Noonan syndrome 1 OMIM:[176876]

About this Structure

3B7O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 18:56:49 2008

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