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3bcz
From Proteopedia
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| - | [[Image:3bcz.gif|left|200px]] | + | [[Image:3bcz.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of Memo''' | + | {{Structure |
| + | |PDB= 3bcz |SIZE=350|CAPTION= <scene name='initialview01'>3bcz</scene>, resolution 2.10Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Residue+D+301'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+A+302'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+A+303'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+B+304'>AC4</scene> and <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+C+305'>AC5</scene> | ||
| + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= MEMO1, C2orf4, NS5ATP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of Memo''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3BCZ is a [ | + | 3BCZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCZ OCA]. |
==Reference== | ==Reference== | ||
| - | Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:[http:// | + | Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18045866 18045866] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peptide binding protein]] | [[Category: peptide binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:58 2008'' |
Revision as of 16:58, 20 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , and | ||||||
| Ligands: | |||||||
| Gene: | MEMO1, C2orf4, NS5ATP7 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Memo
Overview
Memo (mediator of ErbB2-driven cell motility) is a 297-amino-acid protein recently shown to co-precipitate with the C terminus of ErbB2 and be required for ErbB2-driven cell motility. Memo is not homologous to any known signaling proteins, and how it mediates ErbB2 signals is not known. To provide a molecular basis for understanding Memo function, we have determined and report here the 2.1A crystal structure of human Memo and show it be homologous to class III nonheme iron-dependent dioxygenases, a structural class that now includes a zinc-binding protein of unknown function. No metal binding or enzymatic activity can be detected for Memo, but Memo does bind directly to a specific ErbB2-derived phosphopeptide encompassing Tyr-1227 using its vestigial enzymatic active site. Memo thus represents a new class of phosphotyrosine-binding protein.
About this Structure
3BCZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:18045866
Page seeded by OCA on Thu Mar 20 18:57:58 2008
