1gwp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN== | |
| - | + | <StructureSection load='1gwp' size='340' side='right' caption='[[1gwp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1gwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gdz 1gdz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWP FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a43|1a43]], [[1a8o|1a8o]], [[1afv|1afv]], [[1ak4|1ak4]], [[1aum|1aum]], [[1baj|1baj]], [[1hiw|1hiw]], [[2hmx|2hmx]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gwp RCSB], [http://www.ebi.ac.uk/pdbsum/1gwp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The capsid protein (CA) of the mature human immunodeficiency virus (HIV) contains an N-terminal beta-hairpin that is essential for formation of the capsid core particle. CA is generated by proteolytic cleavage of the Gag precursor polyprotein during viral maturation. We have determined the NMR structure of a 283-residue N-terminal fragment of immature HIV-1 Gag (Gag(283)), which includes the intact matrix (MA) and N-terminal capsid (CA(N)) domains. The beta-hairpin is unfolded in Gag(283), consistent with the proposal that hairpin formation occurs subsequent to proteolytic cleavage of Gag, triggering capsid assembly. Comparison of the immature and mature CA(N) structures reveals that beta-hairpin formation induces a approximately 2 A displacement of helix 6 and a concomitant displacement of the cyclophylin-A (CypA)-binding loop, suggesting a possible allosteric mechanism for CypA-mediated destabilization of the capsid particle during infectivity. | ||
| - | + | Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein.,Tang C, Ndassa Y, Summers MF Nat Struct Biol. 2002 Jul;9(7):537-43. PMID:12032547<ref>PMID:12032547</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
==See Also== | ==See Also== | ||
*[[Gag polyprotein|Gag polyprotein]] | *[[Gag polyprotein|Gag polyprotein]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
| - | [[Category: Gitti, R K | + | [[Category: Gitti, R K]] |
| - | [[Category: Lee, B M | + | [[Category: Lee, B M]] |
| - | [[Category: Summers, M F | + | [[Category: Summers, M F]] |
| - | [[Category: Sundquist, W I | + | [[Category: Sundquist, W I]] |
| - | [[Category: Tang, C | + | [[Category: Tang, C]] |
| - | [[Category: Walker, J | + | [[Category: Walker, J]] |
| - | [[Category: Yoo, S | + | [[Category: Yoo, S]] |
[[Category: Amimo-terminal core domain]] | [[Category: Amimo-terminal core domain]] | ||
[[Category: Hiv-1 ca-151]] | [[Category: Hiv-1 ca-151]] | ||
Revision as of 16:44, 21 December 2014
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
| |||||||||||
