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2mh2

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_2mh2| PDB=2mh2 | SCENE= }}
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===Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2===
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The entry 2mh2 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE]] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref>
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Authors: Moktan, H., Guiraldelli, M.F., Eyter, C.A., Zhao, W., Camerini-Otero, R.D., Sung, P., Zhou, D.H., Pezza, R.J.
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==About this Structure==
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[[2mh2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA].
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Description: Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Camerini-Otero, R D.]]
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[[Category: Eyter, C A.]]
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[[Category: Guiraldelli, M F.]]
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[[Category: Moktan, H.]]
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[[Category: Pezza, R J.]]
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[[Category: Sung, P.]]
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[[Category: Zhao, W.]]
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[[Category: Zhou, D H.]]
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[[Category: Dna binding protein]]
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[[Category: Homologous pairing protein]]
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[[Category: Homologous recombination]]
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[[Category: Meiosis]]

Revision as of 09:54, 16 April 2014

Template:STRUCTURE 2mh2

Contents

Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2

Function

[HOP2_MOUSE] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.[1] [2] [3] [4] [5] [6]

About this Structure

2mh2 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Tanaka T, Nakamura T, Takagi H, Sato M. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81. PMID:9345291 doi:http://dx.doi.org/10.1006/bbrc.1997.7447
  2. ↑ Enomoto R, Kinebuchi T, Sato M, Yagi H, Shibata T, Kurumizaka H, Yokoyama S. Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. J Biol Chem. 2004 Aug 20;279(34):35263-72. Epub 2004 Jun 10. PMID:15192114 doi:http://dx.doi.org/10.1074/jbc.M402481200
  3. ↑ Pezza RJ, Petukhova GV, Ghirlando R, Camerini-Otero RD. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. J Biol Chem. 2006 Jul 7;281(27):18426-34. Epub 2006 May 4. PMID:16675459 doi:http://dx.doi.org/M601073200
  4. ↑ Chi P, San Filippo J, Sehorn MG, Petukhova GV, Sung P. Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev. 2007 Jul 15;21(14):1747-57. PMID:17639080 doi:http://dx.doi.org/21/14/1747
  5. ↑ Pezza RJ, Voloshin ON, Vanevski F, Camerini-Otero RD. Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev. 2007 Jul 15;21(14):1758-66. PMID:17639081 doi:http://dx.doi.org/21/14/1758
  6. ↑ Ploquin M, Petukhova GV, Morneau D, Dery U, Bransi A, Stasiak A, Camerini-Otero RD, Masson JY. Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases. Nucleic Acids Res. 2007;35(8):2719-33. Epub 2007 Apr 10. PMID:17426123 doi:http://dx.doi.org/gkm174

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