4coh

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m (Protected "4coh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4coh| PDB=4coh | SCENE= }}
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===Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor===
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The entry 4coh is ON HOLD until Jan 28 2016
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==Function==
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[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512]
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Authors: Vieira, D.F., Choi, J.Y., Roush, W.R., Podust, L.M.
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==About this Structure==
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[[4coh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4COH OCA].
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Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Sterol 14-demethylase]]
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[[Category: Choi, J Y.]]
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[[Category: Podust, L M.]]
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[[Category: Roush, W R.]]
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[[Category: Vieira, D F.]]
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[[Category: Chagas disease]]
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[[Category: Cyp51]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Sterol biosynthesis]]
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[[Category: Transferase]]

Revision as of 09:29, 2 April 2014

Template:STRUCTURE 4coh

Contents

Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor

Function

[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]

About this Structure

4coh is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200

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OCA

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