4n4z

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{{STRUCTURE_4n4z| PDB=4n4z | SCENE= }}
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==Trypanosoma brucei procathepsin B structure solved by Serial Microcrystallography using synchrotron radiation==
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===Trypanosoma brucei procathepsin B structure solved by Serial Microcrystallography using synchrotron radiation===
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<StructureSection load='4n4z' size='340' side='right' caption='[[4n4z]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N4Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hwy|4hwy]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb927.6.560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n4z RCSB], [http://www.ebi.ac.uk/pdbsum/4n4z PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal structure determinations of biological macromolecules are limited by the availability of sufficiently sized crystals and by the fact that crystal quality deteriorates during data collection owing to radiation damage. Exploiting a micrometre-sized X-ray beam, high-precision diffractometry and shutterless data acquisition with a pixel-array detector, a strategy for collecting data from many micrometre-sized crystals presented to an X-ray beam in a vitrified suspension is demonstrated. By combining diffraction data from 80 Trypanosoma brucei procathepsin B crystals with an average volume of 9 microm(3), a complete data set to 3.0 A resolution has been assembled. The data allowed the refinement of a structural model that is consistent with that previously obtained using free-electron laser radiation, providing mutual validation. Further improvements of the serial synchrotron crystallography technique and its combination with serial femtosecond crystallography are discussed that may allow the determination of high-resolution structures of micrometre-sized crystals.
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==About this Structure==
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Serial crystallography on in vivo grown microcrystals using synchrotron radiation.,Gati C, Bourenkov G, Klinge M, Rehders D, Stellato F, Oberthur D, Yefanov O, Sommer BP, Mogk S, Duszenko M, Betzel C, Schneider TR, Chapman HN, Redecke L IUCrJ. 2014 Feb 10;1(Pt 2):87-94. doi: 10.1107/S2052252513033939. eCollection, 2014 Mar 1. PMID:25075324<ref>PMID:25075324</ref>
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[[4n4z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N4Z OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Cathepsin|Cathepsin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Trybb]]
[[Category: Betzel, C.]]
[[Category: Betzel, C.]]
[[Category: Bourenkov, G.]]
[[Category: Bourenkov, G.]]

Revision as of 05:27, 8 October 2014

Trypanosoma brucei procathepsin B structure solved by Serial Microcrystallography using synchrotron radiation

4n4z, resolution 3.30Å

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