4cp3

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m (Protected "4cp3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4cp3| PDB=4cp3 | SCENE= }}
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===The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.===
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{{ABSTRACT_PUBMED_24595451}}
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The entry 4cp3 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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Authors: Evans, S.E., Fairall, L., Goult, B.T., Jamieson, A.G., Ferrigno, P.K., Ford, R., Wagner, S.D., Schwabe, J.W.R.
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==Function==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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Description: The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.
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==About this Structure==
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[[4cp3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CP3 OCA].
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==Reference==
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<ref group="xtra">PMID:024595451</ref><references group="xtra"/><references/>
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[[Category: Evans, S E.]]
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[[Category: Fairall, L.]]
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[[Category: Ferrigno, P K.]]
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[[Category: Ford, R.]]
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[[Category: Goult, B T.]]
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[[Category: Jamieson, A G.]]
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[[Category: Schwabe, J W.R.]]
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[[Category: Wagner, S D.]]
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[[Category: Antibiotic]]
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[[Category: Btb/poz]]
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[[Category: Immune system]]
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[[Category: Inhibitor]]
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[[Category: Rifamycin]]
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[[Category: Smrt]]
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[[Category: Transcriptional repressor]]

Revision as of 08:45, 19 March 2014

Template:STRUCTURE 4cp3

Contents

The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.

Template:ABSTRACT PUBMED 24595451

Disease

[BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Function

[BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.[1] [2]

About this Structure

4cp3 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD. The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain. PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection , 2014. PMID:24595451 doi:http://dx.doi.org/10.1371/journal.pone.0090889
  1. ↑ Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998 Jul 1;12(13):1953-61. PMID:9649500
  2. ↑ Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243 doi:10.1016/j.molcel.2007.12.026

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