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3whw
From Proteopedia
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| - | + | ==MTH1 in complex with Ruthenium-based inhibitor== | |
| - | + | <StructureSection load='3whw' size='340' side='right' caption='[[3whw]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | { | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[3whw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WHW FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RUX:[4-AMINO-2-METHYL-6-(PYRIDIN-2-YL-KAPPAN)QUINAZOLIN-7-YL-KAPPAC~7~](CARBONYL){1-[(2,6-DIMETHOXYPHENOXY)CARBONYL]CYCLOPENTA-2,4-DIEN-1-YL}RUTHENIUM'>RUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zr1|3zr1]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3whw RCSB], [http://www.ebi.ac.uk/pdbsum/3whw PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The probe-based discovery of the first small-molecule inhibitor of the repair enzyme 8-oxo-dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half-sandwich complex. The organometallic inhibitor with low-nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography. | ||
| - | + | An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase.,Streib M, Kraling K, Richter K, Xie X, Steuber H, Meggers E Angew Chem Int Ed Engl. 2014 Jan 3;53(1):305-9. doi: 10.1002/anie.201307849. Epub, 2013 Nov 20. PMID:24258965<ref>PMID:24258965</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[7%2C8-dihydro-8-oxoguanine triphosphatase|7%2C8-dihydro-8-oxoguanine triphosphatase]] | |
| - | [[Category: Kraeling, K | + | == References == |
| - | [[Category: Meggers, E | + | <references/> |
| - | [[Category: Richter, K | + | __TOC__ |
| - | [[Category: Steuber, H | + | </StructureSection> |
| - | [[Category: Streib, M | + | [[Category: Human]] |
| + | [[Category: Kraeling, K]] | ||
| + | [[Category: Meggers, E]] | ||
| + | [[Category: Richter, K]] | ||
| + | [[Category: Steuber, H]] | ||
| + | [[Category: Streib, M]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Mth1]] | [[Category: Mth1]] | ||
[[Category: Organometallic inhibitor]] | [[Category: Organometallic inhibitor]] | ||
Revision as of 18:52, 21 December 2014
MTH1 in complex with Ruthenium-based inhibitor
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