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4m1b
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| - | + | ==Structural Determination of BA0150, a Polysaccharide Deacetylase from Bacillus anthracis== | |
| - | + | <StructureSection load='4m1b' size='340' side='right' caption='[[4m1b]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4m1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1B FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ba0150, BAS0150, BA_0150, GBAA_0150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1b RCSB], [http://www.ebi.ac.uk/pdbsum/4m1b PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram-positive bacteria, allowing them to be unrecognized by host immune systems. Inhibition of these enzymes would disrupt such pathogenic defensive mechanisms and therefore offers a promising route for the development of novel antibiotic therapeutics. Here, the first X-ray crystal structure of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, is reported to 2.0 A resolution. The overall structure maintains the conserved (alpha/beta)8 fold that is characteristic of this family of enzymes. The lack of a catalytic metal ion and a distinctive metal-binding site, however, suggest that this enzyme is not a functional polysaccharide deacetylase. | ||
| - | + | Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis.,Strunk RJ, Piemonte KM, Petersen NM, Koutsioulis D, Bouriotis V, Perry K, Cole KE Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):156-9. doi:, 10.1107/S2053230X13034262. Epub 2014 Jan 21. PMID:24637747<ref>PMID:24637747</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cole, K E.]] | [[Category: Cole, K E.]] | ||
[[Category: Perry, K.]] | [[Category: Perry, K.]] | ||
Revision as of 06:17, 24 September 2014
Structural Determination of BA0150, a Polysaccharide Deacetylase from Bacillus anthracis
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