3fct

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[[Image:3fct.gif|left|200px]]<br /><applet load="3fct" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3fct.gif|left|200px]]
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caption="3fct, resolution 2.40&Aring;" />
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'''MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN'''<br />
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{{Structure
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|PDB= 3fct |SIZE=350|CAPTION= <scene name='initialview01'>3fct</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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3FCT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CD:'>CD</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=MMP:'>MMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCT OCA].
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3FCT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCT OCA].
==Reference==
==Reference==
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Structural and kinetic evidence for strain in biological catalysis., Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC, Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9772166 9772166]
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Structural and kinetic evidence for strain in biological catalysis., Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC, Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9772166 9772166]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: metal chelatase]]
[[Category: metal chelatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:09:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:04:47 2008''

Revision as of 17:04, 20 March 2008

Image:3fct.gif


PDB ID 3fct

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN


Overview

A classic hypothesis for enzyme catalysis is the induction of strain in the substrate. This notion was first expressed by Haldane with the lock and key analogy-"the key does not fit the lock perfectly but exercises a certain strain on it" (1). This mechanism has often been invoked to explain the catalytic efficiency of enzymes but has been difficult to establish conclusively (2-7). Here we describe X-ray crystallographic and mutational studies of an antibody metal chelatase which strongly support the notion that this antibody catalyzes metal ion insertion into the porphyrin ring by inducing strain. Analysis of the germline precursor suggests that this strain mechanism arose during the process of affinity maturation in response to a conformationally distorted N-alkylmesoporphyrin.

About this Structure

3FCT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and kinetic evidence for strain in biological catalysis., Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC, Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:9772166

Page seeded by OCA on Thu Mar 20 19:04:47 2008

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