4ot8

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m (Protected "4ot8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ot8| PDB=4ot8 | SCENE= }}
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===X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine===
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The entry 4ot8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/B4ECY9_BURCJ B4ECY9_BURCJ]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]
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Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
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==About this Structure==
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[[4ot8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OT8 OCA].
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Description: X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine
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[[Category: Glycine hydroxymethyltransferase]]
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[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Seattle structural genomics center for infectious disease]]
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[[Category: Serine hydroxymethyl transferase]]
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[[Category: Ssgcid]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]

Revision as of 07:58, 23 April 2014

Template:STRUCTURE 4ot8

X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine

Function

[B4ECY9_BURCJ] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]

About this Structure

4ot8 is a 4 chain structure. Full crystallographic information is available from OCA.

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OCA

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