1awi
From Proteopedia
(New page: 200px<br /> <applet load="1awi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1awi, resolution 2.2Å" /> '''HUMAN PLATELET PROFI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AWI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AWI OCA]]. | + | 1AWI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Sites: PPA and PPB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AWI OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: profilin]] | [[Category: profilin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:43:13 2007'' |
Revision as of 06:38, 30 October 2007
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HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE
Overview
Profilin, a ubiquitous low molecular weight (13,000-15,000 M(r)) actin, binding protein, regulates the formation of F-actin structures in vivo, and is localized to specific cellular regions through interaction with, proline-rich sequences. Here we report the 2.2 A X-ray structure of the, complex between human platelet profilin (HPP) and a decamer of L-proline, (L-Pro10). The L-Pro10 peptide adopts a left-handed type II poly-L-proline, helix (PPII) and binds to a highly conserved patch of aromatic amino acids, on the surface of profilin. The peptide and actin binding sites reside on, orthogonal surfaces, and L-Pro10 binding does not result in a, conformational rearrangement of HPP. This structure suggests a mechanism, for the localization of profilin and its actin-related activities to ... [(full description)]
About this Structure
1AWI is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Sites: PPA and PPB. Full crystallographic information is available from [OCA].
Reference
Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:9360613
Page seeded by OCA on Tue Oct 30 08:43:13 2007
