Dual specificity protein kinase

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{{STRUCTURE_2x9e| PDB=2x9e | SIZE=400| SCENE= |right|CAPTION=Dual specificity protein kinase TTK kinase domain complex with inhibitor, [[2x9e]] }}
{{STRUCTURE_2x9e| PDB=2x9e | SIZE=400| SCENE= |right|CAPTION=Dual specificity protein kinase TTK kinase domain complex with inhibitor, [[2x9e]] }}
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'''Dual specificity protein kinases''' are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing.
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'''Dual specificity protein kinases''' are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing. The dual specificity protein kinase TTK contains tetra-trico-peptide repeat domain (TPR) which serves as interaction domain between proteins.
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Revision as of 09:16, 3 March 2014

Template:STRUCTURE 2x9e

Dual specificity protein kinases are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing. The dual specificity protein kinase TTK contains tetra-trico-peptide repeat domain (TPR) which serves as interaction domain between proteins.

Contents

3D structures of dual specificity protein kinase

Updated on 03-March-2014

CLK1

1z57 – hCLK1 kinase domain + himenialdizine – human

2vag - hCLK1 kinase domain + indole inhibitor

CLK2

3nr9 – hCLK2 kinase domain

CLK3

2eu9 – hCLK3

2exe – hCLK3 kinase domain, phosphorylated

2wu6, 2wu7 – hCLK3 kinase domain + inhibitor

3raw - hCLK3 kinase domain + leucettine

TTK

3cek, 3dbq – hTTK kinase domain
4b94, 4h7x, 4h7y - hTTK TPR domain
3gfw - hTTK kinase domain + pyrolo-pyridin ligand

3h9f - hTTK kinase domain + pyrimidino-diazepin ligand

2x9e, 3vqu, 3w1f, 4bhz, 4bi0, 4bi1, 4bi2, 4c4e, 4c4f, 4c4g, 4c4h, 4c4i, 4c4j - hTTK kinase domain + inhibitor

2zmc - hTTK catalytic domain

2zmd - hTTK catalytic domain (mutant) + inhibitor

3hmn - hTTK catalytic domain + ATP

3hmo - hTTK catalytic domain + staurosporine

3hmp - hTTK catalytic domain + quinazolin ligand

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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