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4azn
From Proteopedia
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| - | {{STRUCTURE_4azn| PDB=4azn | SCENE= }} | ||
| - | ===Murine epidermal fatty acid-binding protein (FABP5), apo form, poly- his tag-mediated crystal packing=== | ||
| - | {{ABSTRACT_PUBMED_24531463}} | ||
| - | == | + | ==Murine epidermal fatty acid-binding protein (FABP5), apo form, poly- his tag-mediated crystal packing== |
| - | [[4azn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZN OCA]. | + | <StructureSection load='4azn' size='340' side='right' caption='[[4azn]], [[Resolution|resolution]] 2.51Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4azn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AZN FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4azm|4azm]], [[4azo|4azo]], [[4azp|4azp]], [[4azq|4azq]], [[4azr|4azr]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4azn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azn OCA], [http://pdbe.org/4azn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4azn RCSB], [http://www.ebi.ac.uk/pdbsum/4azn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4azn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In addition to binding intracellular fatty acids, fatty-acid-binding proteins (FABPs) have recently been reported to also transport the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), arachidonic acid derivatives that function as neurotransmitters and mediate a diverse set of physiological and psychological processes. To understand how the endocannabinoids bind to FABPs, the crystal structures of FABP5 in complex with AEA, 2-AG and the inhibitor BMS-309403 were determined. These ligands are shown to interact primarily with the substrate-binding pocket via hydrophobic interactions as well as a common hydrogen bond to the Tyr131 residue. This work advances our understanding of FABP5-endocannabinoid interactions and may be useful for future efforts in the development of small-molecule inhibitors to raise endocannabinoid levels. | ||
| - | + | Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.,Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):290-8. doi:, 10.1107/S1399004713026795. Epub 2014 Jan 29. PMID:24531463<ref>PMID:24531463</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4azn" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Fatty acid-binding protein|Fatty acid-binding protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
| - | [[Category: Deutsch, D | + | [[Category: Deutsch, D]] |
| - | [[Category: Kaczocha, M | + | [[Category: Kaczocha, M]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Ojima, I | + | [[Category: Ojima, I]] |
| - | [[Category: Sanson, B | + | [[Category: Sanson, B]] |
| - | [[Category: Sun, J | + | [[Category: Sun, J]] |
| - | [[Category: Wang, T | + | [[Category: Wang, T]] |
[[Category: Beta-barrel]] | [[Category: Beta-barrel]] | ||
[[Category: Beta-clamshell]] | [[Category: Beta-clamshell]] | ||
Revision as of 20:15, 4 August 2016
Murine epidermal fatty acid-binding protein (FABP5), apo form, poly- his tag-mediated crystal packing
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