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4gqj
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| - | ''' | + | ==Complex of a binuclear Ruthenium compound D,D-([mu-(11,11')-bi(dppz)-(1,10-phenanthroline)4-Ru2]4+) bound to d(CGTACG)== |
| + | <StructureSection load='4gqj' size='340' side='right' caption='[[4gqj]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gqj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQJ FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RR2:(MU-11,11-BIDIPYRIDO[3,2-A 2,3-C]PHENAZINE-1KAPPA~2~N~4~,N~5~ 2KAPPA~2~N~4~,N~5~)[TETRAKIS(1,10-PHENANTHROLINE-KAPPA~2~N~1~,N~10~)]DIRUTHENIUM'>RR2</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s80|3s80]], [[3qrn|3qrn]], [[4e1u|4e1u]], [[3u38|3u38]], [[4e7y|4e7y]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqj RCSB], [http://www.ebi.ac.uk/pdbsum/4gqj PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the Delta,Delta enantiomer of the binuclear "light-switch" ruthenium complex [mu-(11,11'-bidppz)(1,10-phenanthroline)4 Ru2 ](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves. | ||
| - | + | Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes.,Boer DR, Wu L, Lincoln P, Coll M Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1949-52. doi: 10.1002/anie.201308070., Epub 2014 Jan 21. PMID:24449275<ref>PMID:24449275</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Boer, D R.]] | ||
| + | [[Category: Coll, M.]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Dna binsinf]] | ||
| + | [[Category: Dna recognition]] | ||
Revision as of 12:03, 18 May 2014
Complex of a binuclear Ruthenium compound D,D-([mu-(11,11')-bi(dppz)-(1,10-phenanthroline)4-Ru2]4+) bound to d(CGTACG)
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