3ull

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[[Image:3ull.gif|left|200px]]<br /><applet load="3ull" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3ull.gif|left|200px]]
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caption="3ull, resolution 2.40&Aring;" />
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'''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN'''<br />
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{{Structure
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|PDB= 3ull |SIZE=350|CAPTION= <scene name='initialview01'>3ull</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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3ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].
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3ULL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].
==Reference==
==Reference==
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Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9033597 9033597]
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Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9033597 9033597]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transit peptide]]
[[Category: transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:07:38 2008''

Revision as of 17:07, 20 March 2008


PDB ID 3ull

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, resolution 2.40Å
Coordinates: save as pdb, mmCIF, xml



HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN


Overview

We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.

About this Structure

3ULL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:9033597

Page seeded by OCA on Thu Mar 20 19:07:38 2008

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