4ogi

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{{STRUCTURE_4ogi| PDB=4ogi | SCENE= }}
{{STRUCTURE_4ogi| PDB=4ogi | SCENE= }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536===
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536===
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{{ABSTRACT_PUBMED_24584101}}
==Disease==
==Disease==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024584101</ref><references group="xtra"/><references/>
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Bountra, C.]]

Revision as of 07:41, 2 April 2014

Template:STRUCTURE 4ogi

Contents

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor BI-2536

Template:ABSTRACT PUBMED 24584101

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4ogi is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ciceri P, Muller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Apr;10(4):305-12. doi: 10.1038/nchembio.1471. Epub 2014 Mar, 2. PMID:24584101 doi:http://dx.doi.org/10.1038/nchembio.1471
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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