4ooj
From Proteopedia
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| - | + | ==Crystal structure of the N-terminal domain of the Legionella pneumophila protein SidC at 2.4A resolution== | |
| - | + | <StructureSection load='4ooj' size='340' side='right' caption='[[4ooj]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ooj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOJ FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sidC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooj RCSB], [http://www.ebi.ac.uk/pdbsum/4ooj PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Gram-negative bacterium Legionella pneumophila is the causative agent of Legionnaires' disease. During infection of eukaryotic cells, the bacterium releases about 300 different bacterial effector molecules that aid in the establishment of the Legionella-containing vacuole (LCV) among which SidC is one of these secreted proteins. However, apart from membrane lipid binding the function of SidC remains elusive. In order to characterize SidC further, we have determined the crystal structure of the N-terminal domain of SidC (amino acids 1-609, referred to as SidC-N) at 2.4A resolution. SidC-N reveals a novel fold in which 4 potential subdomains (A-D) are arranged in a crescent-like structure. None of these subdomains currently has any known structural homologues, raising the question of how this fold has evolved. These domains are highly interconnected, with a low degree of flexibility towards each other. Due to the extended arrangement of the subdomains, SidC-N may contain multiple binding sites for potential interaction partners. | ||
| - | + | The structure of the N-terminal domain of the Legionella protein SidC.,Gazdag EM, Schobel S, Shkumatov AV, Goody RS, Itzen A J Struct Biol. 2014 Apr;186(1):188-94. doi: 10.1016/j.jsb.2014.02.003. Epub 2014 , Feb 17. PMID:24556577<ref>PMID:24556577</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Legph]] | ||
[[Category: Gazdag, E M.]] | [[Category: Gazdag, E M.]] | ||
[[Category: Goody, R S.]] | [[Category: Goody, R S.]] | ||
Revision as of 06:45, 13 August 2014
Crystal structure of the N-terminal domain of the Legionella pneumophila protein SidC at 2.4A resolution
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