4po6

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m (Protected "4po6" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4po6| PDB=4po6 | SCENE= }}
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===Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide===
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The entry 4po6 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
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Authors: Wallweber, H.J.A., Lupardus, P.J.
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==Function==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> [[http://www.uniprot.org/uniprot/INAR1_HUMAN INAR1_HUMAN]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
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Description: Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
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==About this Structure==
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[[4po6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Lupardus, P J.]]
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[[Category: Wallweber, H J.A.]]
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[[Category: Cytokine]]
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[[Category: Ferm]]
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[[Category: Intracellular]]
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[[Category: Kinase]]
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[[Category: Receptor]]
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[[Category: Sh2]]
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[[Category: Transferase]]

Revision as of 09:41, 2 April 2014

Template:STRUCTURE 4po6

Contents

Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide

Disease

[TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

Function

[TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.[1] [INAR1_HUMAN] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

About this Structure

4po6 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 1994 Dec;14(12):8133-42. PMID:7526154

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