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3td0

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{{STRUCTURE_3td0| PDB=3td0 | SCENE= }}
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==Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site==
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===Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site===
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<StructureSection load='3td0' size='340' side='right' caption='[[3td0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22110016}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3td0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TD0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bnl|3bnl]], [[3td1|3td1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3td0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3td0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3td0 RCSB], [http://www.ebi.ac.uk/pdbsum/3td0 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.
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==About this Structure==
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A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides.,Kondo J Angew Chem Int Ed Engl. 2011 Nov 23. doi: 10.1002/anie.201106084. PMID:22110016<ref>PMID:22110016</ref>
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[[3td0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD0 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:022110016</ref><references group="xtra"/><references/>
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</div>
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[[Category: Kondo, J.]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Kondo, J]]
[[Category: Decoding]]
[[Category: Decoding]]
[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Rna]]
[[Category: Rna]]

Revision as of 11:05, 4 January 2015

Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site

3td0, resolution 1.60Å

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