This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2lyg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Fuc_TBA== | |
| - | === | + | <StructureSection load='2lyg' size='340' side='right' caption='[[2lyg]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LYG FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [http://www.ebi.ac.uk/pdbsum/2lyg PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands. | ||
| - | + | Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Avio, A | + | == References == |
| - | [[Category: Eritja, R | + | <references/> |
| - | [[Category: Gomez-Pinto, I | + | __TOC__ |
| - | [[Category: Gonzalez-Ibaez, C | + | </StructureSection> |
| - | [[Category: Lucas, R | + | [[Category: Avio, A]] |
| - | [[Category: Morales, J | + | [[Category: Eritja, R]] |
| - | [[Category: Vengut-Climent, E | + | [[Category: Gomez-Pinto, I]] |
| + | [[Category: Gonzalez-Ibaez, C]] | ||
| + | [[Category: Lucas, R]] | ||
| + | [[Category: Morales, J]] | ||
| + | [[Category: Vengut-Climent, E]] | ||
[[Category: Carbohydrate-dna interaction]] | [[Category: Carbohydrate-dna interaction]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: G-quadruplex structure]] | [[Category: G-quadruplex structure]] | ||
Revision as of 13:28, 19 January 2015
Fuc_TBA
| |||||||||||
