Kinesin
From Proteopedia
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{{STRUCTURE_2zfi | PDB=2zfi | SIZE=400 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }} | {{STRUCTURE_2zfi | PDB=2zfi | SIZE=400 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }} | ||
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'''3D Structure of Kinesin''' <br /> | '''3D Structure of Kinesin''' <br /> | ||
| - | The image | + | The image is a Crystal Structure of the Kif1A Motor Domain Before Mg Release ([[2zfi]]) |
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== Kinesin == | == Kinesin == | ||
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[[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called '''Kar3'''. '''Eg5''' or '''KIF11''' is a kinesin ([[Kinesin-5]]) which participates in mitosis. '''KCBP''' is a '''Kinesin-like Calmodulin Binding Protein'''. '''NOD''' is a Drosophila chromosome-associated kinesin. | [[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called '''Kar3'''. '''Eg5''' or '''KIF11''' is a kinesin ([[Kinesin-5]]) which participates in mitosis. '''KCBP''' is a '''Kinesin-like Calmodulin Binding Protein'''. '''NOD''' is a Drosophila chromosome-associated kinesin. | ||
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== 3D Structures of Kinesin == | == 3D Structures of Kinesin == | ||
Revision as of 07:15, 19 August 2014
3D Structure of Kinesin
The image is a Crystal Structure of the Kif1A Motor Domain Before Mg Release (2zfi)
Contents |
Kinesin
Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called Kar3. Eg5 or KIF11 is a kinesin (Kinesin-5) which participates in mitosis. KCBP is a Kinesin-like Calmodulin Binding Protein. NOD is a Drosophila chromosome-associated kinesin.
3D Structures of Kinesin
Updated on 19-August-2014
Kinesin heavy chain (KIF)
2zfi, 2zfj, 2zfk, 2zfl, 2zfm – mKIF1A – mouse
2vvg – KIF2 MD – Giardia intestinalis
2g1l - hKIF1C FHA domain
2owm – NcKIF1C MD – Neurospora crassa
1goj – NcKIF MD
3bfn – hKIF22 MD
3b6u, 3b6v – hKIF3B MD
2rep – hKIFC1 MD
2eh0 - hKIF1B FHA domain – NMR
2edu – hKIF22 C-terminal – NMR
2v14 – hKIF16B
2heh – hKIF2C
2cow – hKIF13B CAP-gly domain – NMR
1bg2 – hKIF MD
3kin, 2kin – rKIF MD - rat
1ry6 – KIF MD – Plasmodium falciparum
2ncd, 1cz7 – DmKIF MD non-claret disjuctional (NCD) dimer – Drosophila melanogaster
2y5w, 2y65 - DmKIF MD
Kinesin heavy chain complex with nucleotide
3gbj – hKIF13B MD+ADP – human
1vfv, 1vfw – mKIF1A MD+Mg-AMPPNP
1vfx - mKIF1A MD+ADP-Mg-AlFx
1vfz - mKIF1A MD+ADP-Mg-VO4
1v8j – mKIF2C MD+Mg-ADP
1i5s - mKIF2C MD (mutant)+Mg-ADP
1i6i - mKIF2C MD (mutant)+Mg-AMPPCP
1v8k - mKIF2C MD+Mg-AMPPNP
3zfc, 3zfd – mKIF4 MD+Mg-AMPPNP
2cjo – hKIF13+inhibitor 30
2nr8 – hKIF9+ADP
2h58 – hKIFC3+ADP
2gry – hKIF2+ADP
2hfx – pKIF1A head+AMPPNP – pig
2hxh - pKIF1A head+ADP
Kinesin heavy chain complex with protein
2wbe – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow
1ia0 – KIF1A MD+Tubulin A+Tubulin B+ATP - pig
3edl – cKIF MD+ Tubulin A+Tubulin B – EM
4hna – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4
2p4n – hKIF+ Tubulin A+Tubulin B – EM docking
1mkj – hKIF MD+docked FNL
1n6m – DmKIF MD+FNL
4atx - rKIF MD+ Tubulin A+Tubulin B – EM
Kinesin light chain (KLC)
3edt – hKLC2
3ceq, 3nf1 – hKLC2 TPR domain
3zfw - mKLC2 TPR domain + peptide
Kinesin-14
1f9t, 1f9u, 1f9v, 1f9w, 3kar - Kar3 MD (mutant) - yeast
3l1c – DmNCD (mutant)
Eg5
3ken - hKIF11 MD+S-trityl-L-cysteine
2q2y, 2fky, 2q2z, 2g1q, 2fl2, 2fl6, 1yrs - hKIF11+inhibitors
2pg2 - hKIF11+inhibitor 15+ADP
2uyi - hKIF11+inhibitor 33+ADP
2uym - hKIF11+inhibitor 37+ADP
2ieh - hKIF11+inhibitor (R)-mon97
2fme, 3l9h - hKIF11+quinoline inhibitor
1x88, 1q0b - hKIF11 MD+MgADP+monastrol
3k3b - hKIF11 MD+tetrahydro-beta-carboline
3hqd - hKIF11 MD+AMPPNP+Mg
1ii6 - hKIF11 MD+ADP+Mg
3k5e - hKIF11 MD+ADP+enastrol
KCBP
3h4s – KCBP+ADP+Mg – Arabidopsis thaliana
NOD
3dc4 – DmNOD catalytic core domain+ADP
3dcb - DmNOD catalytic core domain+AMPPNP
3dco - DmNOD catalytic core domain+ cTubulin A+cTubulin B
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky
