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User:Alexander Rudecki/Sandbox 1
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | ''Drosophila melanogaster'' glutaminyl cyclase (DromeQC) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of QC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies. | + | ''Drosophila melanogaster'' glutaminyl cyclase (DromeQC) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of QC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers<ref>Schilling, S., Zeitschel, U., Hoffmann, T., Heiser, U., Francke, M., Kehlen, A., Holzer, M., Hutter-Paier, B., Prokesch, M., Windisch, M., Jagla, W., Schlenzig, D., Lindner, C., Rudolph, T., Reuter, G., Cynis, H., Montag, D., Demuth, H. U., and Rossner, S. (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Aà and Alzheimer’s disease-like pathology. Nat. Med. 14, 1106"1111</ref>. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies. |
| - | ===Gene=== | + | ===Gene=== |
==Structure== | ==Structure== | ||
<StructureSection load='3rec' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3rec' size='340' side='right' caption='Caption for this structure' scene=''> | ||
Revision as of 19:32, 23 March 2014
Introduction
Drosophila melanogaster glutaminyl cyclase (DromeQC) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of QC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers[1]. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies.
Gene
Structure
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