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User:Alexander Rudecki/Sandbox 1
From Proteopedia
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Revision as of 19:37, 23 March 2014
Contents |
Introduction
Drosophila melanogaster glutaminyl cyclase (DromeQC) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of QC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers[1]. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies.
Gene
Structure
References
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