6tmn

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[[Image:6tmn.gif|left|200px]]<br /><applet load="6tmn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:6tmn.gif|left|200px]]
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caption="6tmn, resolution 1.6&Aring;" />
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'''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND'''<br />
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{{Structure
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|PDB= 6tmn |SIZE=350|CAPTION= <scene name='initialview01'>6tmn</scene>, resolution 1.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27]
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|GENE=
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}}
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'''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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6TMN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMN OCA].
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6TMN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMN OCA].
==Reference==
==Reference==
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Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3810156 3810156]
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Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3810156 3810156]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermolysin]]
[[Category: Thermolysin]]
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[[Category: hydrolase (metalloproteinase)]]
[[Category: hydrolase (metalloproteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:16:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:14:06 2008''

Revision as of 17:14, 20 March 2008

Image:6tmn.gif


PDB ID 6tmn

Drag the structure with the mouse to rotate
, resolution 1.6Å
Ligands: and
Activity: Thermolysin, with EC number 3.4.24.27
Coordinates: save as pdb, mmCIF, xml



STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND


Overview

The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.

About this Structure

6TMN is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

Page seeded by OCA on Thu Mar 20 19:14:06 2008

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