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4msv
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of FASL and DcR3 complex== | |
| - | === | + | <StructureSection load='4msv' size='340' side='right' caption='[[4msv]], [[Resolution|resolution]] 2.50Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[4msv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSV FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4en0|4en0]], [[3mhd|3mhd]], [[4j6g|4j6g]], [[4kgg|4kgg]], [[4kgq|4kgq]], [[3k51|3k51]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF6B, DCR3, TR6, UNQ186/PRO212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FASLG, APT1LG1, CD95L, FASL, TNFSF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4msv RCSB], [http://www.ebi.ac.uk/pdbsum/4msv PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref> | [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Bhosle, R C | + | [[Category: Bhosle, R C]] |
| - | [[Category: Bonanno, J B | + | [[Category: Bonanno, J B]] |
| - | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network | + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] |
| - | [[Category: Liu, W | + | [[Category: Liu, W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Nathenson, S G | + | [[Category: Nathenson, S G]] |
| - | [[Category: Ramagopal, U A | + | [[Category: Ramagopal, U A]] |
| - | [[Category: Zhan, C | + | [[Category: Zhan, C]] |
[[Category: Atoms-to-animals: the immune function network]] | [[Category: Atoms-to-animals: the immune function network]] | ||
[[Category: Bind tnf receptor fa]] | [[Category: Bind tnf receptor fa]] | ||
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[[Category: Jelly-roll fold]] | [[Category: Jelly-roll fold]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
| - | [[Category: New york structural genomic]] | ||
| - | [[Category: New york structural genomics research consortium]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
| - | [[Category: Protein structure initiative]] | + | [[Category: PSI, Protein structure initiative]] |
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Research consortium]] | [[Category: Research consortium]] | ||
[[Category: Secreted protein]] | [[Category: Secreted protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Tnf]] | [[Category: Tnf]] | ||
[[Category: Tnf supe cd95l]] | [[Category: Tnf supe cd95l]] | ||
Revision as of 08:34, 5 January 2015
Crystal structure of FASL and DcR3 complex
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Categories: Human | Almo, S C | Bhosle, R C | Bonanno, J B | IFN, Atoms-to-Animals:.The Immune Function Network | Liu, W | Structural genomic | Nathenson, S G | Ramagopal, U A | Zhan, C | Atoms-to-animals: the immune function network | Bind tnf receptor fa | Cd95l | Cytokine | Dcr3 | Fas ligand | Fasl | Ifn | Immune system | Immunity | Jelly-roll fold | Membrane | Nysgrc | PSI, Protein structure initiative | Psi-biology | Research consortium | Secreted protein | Tnf | Tnf supe cd95l | Tnf superfamily | Tnf6 | Tnfr
