6q21

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[[Image:6q21.gif|left|200px]]<br /><applet load="6q21" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:6q21.gif|left|200px]]
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caption="6q21, resolution 1.95&Aring;" />
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'''MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS'''<br />
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{{Structure
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|PDB= 6q21 |SIZE=350|CAPTION= <scene name='initialview01'>6q21</scene>, resolution 1.95&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER'>GCP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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6Q21 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GCP:'>GCP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q21 OCA].
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6Q21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q21 OCA].
==Reference==
==Reference==
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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins., Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH, Science. 1990 Feb 23;247(4945):939-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2406906 2406906]
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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins., Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH, Science. 1990 Feb 23;247(4945):939-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2406906 2406906]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: oncogene protein]]
[[Category: oncogene protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:16:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:14:01 2008''

Revision as of 17:14, 20 March 2008

Image:6q21.gif


PDB ID 6q21

Drag the structure with the mouse to rotate
, resolution 1.95Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS


Contents

Overview

Ras proteins participate as a molecular switch in the early steps of the signal transduction pathway that is associated with cell growth and differentiation. When the protein is in its GTP complexed form it is active in signal transduction, whereas it is inactive in its GDP complexed form. A comparison of eight three-dimensional structures of ras proteins in four different crystal lattices, five with a nonhydrolyzable GTP analog and three with GDP, reveals that the "on" and "off" states of the switch are distinguished by conformational differences that span a length of more than 40 A, and are induced by the gamma-phosphate. The most significant differences are localized in two regions: residues 30 to 38 (the switch I region) in the second loop and residues 60 to 76 (the switch II region) consisting of the fourth loop and the short alpha-helix that follows the loop. Both regions are highly exposed and form a continuous strip on the molecular surface most likely to be the recognition sites for the effector and receptor molecule(or molecules). The conformational differences also provide a structural basis for understanding the biological and biochemical changes of the proteins due to oncogenic mutations, autophosphorylation, and GTP hydrolysis, and for understanding the interactions with other proteins.

Disease

Known diseases associated with this structure: Bladder cancer, somatic OMIM:[190020], Costello syndrome OMIM:[190020], Thyroid carcinoma, follicular, somatic OMIM:[190020]

About this Structure

6Q21 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins., Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH, Science. 1990 Feb 23;247(4945):939-45. PMID:2406906

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