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4ctj

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Revision as of 09:39, 16 April 2014

Template:STRUCTURE 4ctj

Contents

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9

Template:ABSTRACT PUBMED 24704437

Function

[A9LIE0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]

About this Structure

4ctj is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Coutard B, Decroly E, Li C, Sharff A, Lescar J, Bricogne G, Barral K. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery. Antiviral Res. 2014 Apr 1. pii: S0166-3542(14)00087-4. doi:, 10.1016/j.antiviral.2014.03.013. PMID:24704437 doi:http://dx.doi.org/10.1016/j.antiviral.2014.03.013

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OCA

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