9ant
From Proteopedia
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| - | [[Image:9ant.gif|left|200px]] | + | [[Image:9ant.gif|left|200px]] |
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| - | '''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX''' | + | {{Structure |
| + | |PDB= 9ant |SIZE=350|CAPTION= <scene name='initialview01'>9ant</scene>, resolution 2.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 9ANT is a [ | + | 9ANT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA]. |
==Reference== | ==Reference== | ||
| - | Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex., Fraenkel E, Pabo CO, Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:[http:// | + | Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex., Fraenkel E, Pabo CO, Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9699632 9699632] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: homeodomain]] | [[Category: homeodomain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:16:08 2008'' |
Revision as of 17:16, 20 March 2008
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| , resolution 2.40Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
Overview
Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.
About this Structure
9ANT is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex., Fraenkel E, Pabo CO, Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:9699632
Page seeded by OCA on Thu Mar 20 19:16:08 2008
