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[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]] | [[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]] | ||
| - | Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of esterases within the hydrolase family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in atherosclerosis, diabetes, and obesity. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> | + | Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase hydrolase] family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in atherosclerosis, diabetes, and obesity. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> |
Briefly, binding of catecholamines to β-adrenergic receptors coupled with [http://www.proteopedia.org/wiki/index.php/Adenylate_Cyclase adenylate cyclase] (AC) stimulates G-proteins to increase the levels of cystolic [http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. Elevated levels of cAMP leads to an activation [http://www.proteopedia.org/wiki/index.php/Protein_kinase_A protein kinase A] (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. <ref name="Holm">PMID:14641008</ref> | Briefly, binding of catecholamines to β-adrenergic receptors coupled with [http://www.proteopedia.org/wiki/index.php/Adenylate_Cyclase adenylate cyclase] (AC) stimulates G-proteins to increase the levels of cystolic [http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. Elevated levels of cAMP leads to an activation [http://www.proteopedia.org/wiki/index.php/Protein_kinase_A protein kinase A] (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. <ref name="Holm">PMID:14641008</ref> | ||
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* [http://en.wikipedia.org/wiki/Hormone_sensitive_lipase Hormone-sensitive lipase] | * [http://en.wikipedia.org/wiki/Hormone_sensitive_lipase Hormone-sensitive lipase] | ||
* [http://proteopedia.org/wiki/index.php/Lipase Lipase] | * [http://proteopedia.org/wiki/index.php/Lipase Lipase] | ||
| + | * [http://www.proteopedia.org/wiki/index.php/Category:Esterase Other esterases] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 00:23, 1 April 2014
Contents |
Introduction to hormone-sensitive lipase
Image:HPL Movie0006.png
Hormone-Sensitive Lipase
Hormone-sensitive lipases (HSL) represent a class of esterases within the hydrolase family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various catecholamines and inhibited by insulin. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in atherosclerosis, diabetes, and obesity. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. [1]
Briefly, binding of catecholamines to β-adrenergic receptors coupled with adenylate cyclase (AC) stimulates G-proteins to increase the levels of cystolic cAMP. Elevated levels of cAMP leads to an activation protein kinase A (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. [2]
Structure of hormone-sensitive lipase
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Inhibition of hormone-sensitive lipase
Additional pages about hormone-sensitive lipase
References
- ↑ Yeaman SJ. Hormone-sensitive lipase--new roles for an old enzyme. Biochem J. 2004 Apr 1;379(Pt 1):11-22. PMID:14725507 doi:http://dx.doi.org/10.1042/BJ20031811
- ↑ Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans. 2003 Dec;31(Pt 6):1120-4. PMID:14641008 doi:http://dx.doi.org/10.1042/
- ↑ Nam KH, Kim MY, Kim SJ, Priyadarshi A, Kwon ST, Koo BS, Yoon SH, Hwang KY. Structural and functional analysis of a novel hormone-sensitive lipase from a metagenome library. Proteins. 2009 Mar;74(4):1036-40. PMID:19089974 doi:http://dx.doi.org/10.1002/prot.22313
