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Sandbox Reserved 191

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=Introduction=
=Introduction=
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'''<scene name='43/436866/Overall-3-rainbow/1'>Palmitoyl-protein thioesterase 1 (PPT-1)</scene>''' is a small glycoprotein [[hydrolase]] that breaks the thioester bond between cysteine [[amino acids]] and <scene name='43/436866/Palmitic_acid_self/1'>Palmitic Acid</scene> (Newest). It is a homodimer that is composed primarily of ''alpha helices and beta sheets''(Blue like to PDB) (PDB)and is found in the lysosmes of the cell's of the central nervous system. It has a hydrophobic groove that allows the Palmitic Acid to bind to the hydrolyase, exposing the thioester bond to the catalytic triad. PPT-1 is an important hydrolyae in that it removes Palmatic Acid from proteins. When PPT-1 is not functioning properly, the lipid modified proteins can build up in the cells and cause Infantile whatever<ref name="mutations">PMID:10781062</ref>
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'''<scene name='43/436866/Overall-3-rainbow/1'>Palmitoyl-protein thioesterase 1 (PPT-1)</scene>''' is a small glycoprotein [[hydrolase]] that breaks the thioester bond between cysteine [[amino acids]] and <scene name='43/436866/Palmitic_acid_self/1'>Palmitic Acid</scene><ref name="newest">PMID:24083319</ref>. It is a homodimer that is composed primarily of ''alpha helices and beta sheets''(Blue like to PDB) (PDB)and is found in the lysosmes of the cell's of the central nervous system. It has a hydrophobic groove that allows the Palmitic Acid to bind to the hydrolyase, exposing the thioester bond to the catalytic triad. PPT-1 is an important hydrolyae in that it removes Palmatic Acid from proteins. When PPT-1 is not functioning properly, the lipid modified proteins can build up in the cells and cause Infantile whatever<ref name="mutations">PMID:10781062</ref>
[[Image:Protopedia surface.png|400px|left|thumb|Surface view of PPT-1 showing the hydrophobic groove]]
[[Image:Protopedia surface.png|400px|left|thumb|Surface view of PPT-1 showing the hydrophobic groove]]

Revision as of 02:26, 2 April 2014

This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200.
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Palmitoyl-protein thioesterase 1 (PPT-1)

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References

  1. ↑ Wang R, Borazjani A, Matthews AT, Mangum LC, Edelmann MJ, Ross MK. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry. 2013 Oct 29;52(43):7559-74. doi: 10.1021/bi401138s. Epub 2013 Oct, 18. PMID:24083319 doi:http://dx.doi.org/10.1021/bi401138s
  2. ↑ 2.0 2.1 Bellizzi JJ 3rd, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4573-8. PMID:10781062 doi:10.1073/pnas.080508097
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