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4ctk

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ctk| PDB=4ctk | SCENE= }}
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===DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4===
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{{ABSTRACT_PUBMED_24704437}}
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The entry 4ctk is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/A9LIE0_9FLAV A9LIE0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]
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Authors: Barral, K., Bricogne, G., Sharff, A.
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==About this Structure==
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[[4ctk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTK OCA].
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Description: DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4
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==Reference==
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<ref group="xtra">PMID:024704437</ref><references group="xtra"/><references/>
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[[Category: Barral, K.]]
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[[Category: Bricogne, G.]]
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[[Category: Sharff, A.]]
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[[Category: Antiviral screening]]
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[[Category: Dengue virus]]
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[[Category: Fragment-based drug discovery]]
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[[Category: Ns5 methyltransferase]]
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[[Category: Transferase]]

Revision as of 09:49, 16 April 2014

Template:STRUCTURE 4ctk

Contents

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4

Template:ABSTRACT PUBMED 24704437

Function

[A9LIE0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]

About this Structure

4ctk is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Coutard B, Decroly E, Li C, Sharff A, Lescar J, Bricogne G, Barral K. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery. Antiviral Res. 2014 Apr 1. pii: S0166-3542(14)00087-4. doi:, 10.1016/j.antiviral.2014.03.013. PMID:24704437 doi:http://dx.doi.org/10.1016/j.antiviral.2014.03.013

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OCA

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