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3j65
From Proteopedia
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| - | {{STRUCTURE_3j65| PDB=3j65 | SCENE= }}
| + | #REDIRECT [[4v7f]] This PDB entry is obsolete and replaced by 4v7f |
| - | ===Arx1 pre-60S particle. This entry contains the r-proteins and biogenesis factors.===
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| - | {{ABSTRACT_PUBMED_24662372}}
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/RL5_YEAST RL5_YEAST]] Binds 5S RNA and is required for 60S subunit assembly. [[http://www.uniprot.org/uniprot/RLP7_YEAST RLP7_YEAST]] Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.<ref>PMID:11087857</ref> [[http://www.uniprot.org/uniprot/MRT4_YEAST MRT4_YEAST]] Involved in mRNA turnover and ribosome assembly. [[http://www.uniprot.org/uniprot/RLP24_YEAST RLP24_YEAST]] Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.<ref>PMID:12808088</ref> [[http://www.uniprot.org/uniprot/RL25_YEAST RL25_YEAST]] This protein binds to a specific region on the 26S rRNA. [[http://www.uniprot.org/uniprot/IF6_YEAST IF6_YEAST]] Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.<ref>PMID:10085284</ref> <ref>PMID:11779510</ref> <ref>PMID:11238882</ref> <ref>PMID:17353896</ref> <ref>PMID:18256024</ref> <ref>PMID:11101899</ref> [[http://www.uniprot.org/uniprot/RL12A_YEAST RL12A_YEAST]] This protein binds directly to 26S ribosomal RNA.[HAMAP-Rule:MF_00736] [[http://www.uniprot.org/uniprot/NOG1_YEAST NOG1_YEAST]] Involved in the biogenesis of the 60S ribosomal subunit.<ref>PMID:12808088</ref> [[http://www.uniprot.org/uniprot/ARX1_YEAST ARX1_YEAST]] Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.<ref>PMID:12374754</ref> <ref>PMID:16648468</ref> [[http://www.uniprot.org/uniprot/RL4A_YEAST RL4A_YEAST]] Participates in the regulation of the accumulation of its own mRNA.<ref>PMID:2065661</ref> [[http://www.uniprot.org/uniprot/RL37A_YEAST RL37A_YEAST]] Binds to the 23S rRNA (By similarity). [[http://www.uniprot.org/uniprot/NLE1_YEAST NLE1_YEAST]] Involved in processing and efficient intra-nuclear transport or pre-60S ribosomal subunits. Forms a complex with REA1 which is essential for ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.<ref>PMID:16221974</ref> <ref>PMID:19737519</ref> <ref>PMID:20542003</ref> [[http://www.uniprot.org/uniprot/RL11A_YEAST RL11A_YEAST]] Binds to 5S ribosomal RNA. | + | |
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| - | ==About this Structure==
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| - | [[3j65]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J65 OCA].
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| - | ==Reference==
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| - | <ref group="xtra">PMID:024662372</ref><references group="xtra"/><references/>
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| - | [[Category: Saccharomyces cerevisiae]]
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| - | [[Category: Bange, G.]]
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| - | [[Category: Beckmann, R.]]
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| - | [[Category: Berninghausen, O.]]
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| - | [[Category: Bradatsch, B.]]
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| - | [[Category: Holdermann, I.]]
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| - | [[Category: Hurt, E.]]
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| - | [[Category: Leidig, C.]]
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| - | [[Category: Sinning, I.]]
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| - | [[Category: Thoms, M.]]
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| - | [[Category: 60s biogenesis]]
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| - | [[Category: Arx1]]
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| - | [[Category: Eif6]]
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| - | [[Category: Mrt4]]
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| - | [[Category: Nog1]]
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| - | [[Category: Ribosome]]
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| - | [[Category: Rlp24]]
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| - | [[Category: Rlp7]]
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| - | [[Category: Rsa4]]
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| - | [[Category: Tif6]]
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Current revision
- REDIRECT 4v7f This PDB entry is obsolete and replaced by 4v7f
