4pxt

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'''Unreleased structure'''
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{{STRUCTURE_4pxt| PDB=4pxt | SCENE= }}
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===Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers===
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{{ABSTRACT_PUBMED_24714498}}
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The entry 4pxt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/KL61_DROME KL61_DROME]] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
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Authors: Scholey, J.E., Nithianantham, S., Scholey, J.M., Al-Bassam, J.
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==About this Structure==
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[[4pxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXT OCA].
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Description: Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
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==Reference==
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<ref group="xtra">PMID:024714498</ref><references group="xtra"/><references/>
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[[Category: Al-Bassam, J.]]
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[[Category: Nithianantham, S.]]
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[[Category: Scholey, J E.]]
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[[Category: Scholey, J M.]]
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[[Category: Anti-parallel four-helix bundle]]
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[[Category: Bipolar assembly domain of kinesin-5]]
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[[Category: Bipolar tetramer]]
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[[Category: Cell cycle]]
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[[Category: Coiled-coil]]
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[[Category: Crosslinking adjacent microtubules into bundles throughout the mitotic spindle]]
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[[Category: Kinesin-5 functions via a sliding filament mechanism]]
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[[Category: Microtubule]]

Revision as of 07:40, 23 April 2014

Template:STRUCTURE 4pxt

Contents

Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers

Template:ABSTRACT PUBMED 24714498

Function

[KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.

About this Structure

4pxt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 8;3:e02217. doi: 10.7554/eLife.02217. PMID:24714498

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OCA

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