4q0o

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m (Protected "4q0o" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
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<StructureSection load='4q0o' size='340' side='right' caption='[[4q0o]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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The entry 4q0o is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. <br>
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Authors: Filippakopoulos, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0n|4q0n]]</td></tr>
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Description: Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp, S.]]
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[[Category: Picaud, S.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Baf180]]
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[[Category: Brg1-associated factor 180]]
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[[Category: Bromodomain]]
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[[Category: Chromatin regulator]]
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[[Category: Dna-binding]]
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[[Category: Nucleus]]
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[[Category: Pb1]]
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[[Category: Pbrm1]]
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[[Category: Polybromo 1 isoform 1]]
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[[Category: Polybromo-1d]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]

Revision as of 08:24, 7 May 2014

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

4q0o, resolution 1.83Å

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